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Scorsone was born in Toronto, Ontario. She is the middle child of five in her family. Her 4 siblings include: 2 older twin sisters and 2 younger siblings: a sister and a brother.One of her older sisters is the actress Francesca Scorsone (b. 1977)[4] She attended the Cardinal Carter Academy for the Arts in Toronto where she starred in Oklahoma! and several other productions, as well as alternative school Subway Academy II. In addition, she attended Trinity College in the University of Toronto, majoring in Literary Studies and minoring in Philosophy,[5] and in 2005 finished her studies there.

Scorsone's first TV appearances were regular guest spots as a child on the Canadian children's TV show Mr. Dressup starting at age eight.In 1998, she had a role in one of CBC radio's Mystery Project shows called, Peggy Delaney. Scorsone played the estranged fifteen-year-old daughter, Amber, who comes from Vancouver to stay with her mom for a school term in Toronto.

Scorsone had her breakthrough after landing the leading role in the Lifetime crime drama series 1-800-Missing, from 2003 to 2006. She played the part of Jess Mastriani, a young woman who sees missing persons in visions. After Jess saved some missing persons, she joined the FBI, where a special squad was formed around her, to find missing persons. In 2009, she starred as Alice Hamilton on the Showcase TV miniseries Alice which was later broadcast on Syfy in America.

In 2010, Scorsone joined the cast of Shonda Rhimes' drama series Private Practice in the recurring role of Amelia Shepherd, the sister of Derek Shepherd from Grey's Anatomy.She was cast after Eric Stoltz, who was directing one of the show's episodes, heard about the role of Amelia and remembered Scorsone from working with her on My Horrible Year!. He mentioned her to Shonda Rhimes and commented on the resemblance Scorsone had to Patrick Dempsey (the actor who plays Derek Shepherd) As of July 2010, Scorsone had been promoted to series regular for Private Practice.She appeared in the third episode of the seventh season of Grey's Anatomy where she and Derek started to reconcile their differences.

In March 2014, Scorsone returned to Grey's Anatomy after a 3-year absence as a recurring guest star. In June of the same year, it was announced that she was promoted to series regular status for the show's 11th season.

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